Cryo-EM has transformed structural biology by enabling atomic-resolution imaging of macromolecules without requiring crystallization. The method involves flash-freezing samples in vitreous ice and visualizing them under transmission electron microscopes. Advances in direct electron detectors and image reconstruction algorithms have made Cryo-EM a preferred modality for studying membrane proteins, large assemblies, and viral particles. Thermo Fisher Scientific is a leader in this space, offering flagship systems like the Titan Krios and Talos Arctica, known for automation and high-throughput capabilities. These instruments have become critical assets for core facilities and research consortia. Between 2018 and 2024, NIH’s Transformative High-Resolution Cryo-Electron Microscopy Program…

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